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Korendijk, Elly

Robustness issues for cluster randomised trials

Elly Korendijk (PhD)
Department of Methodology & Statistics
Faculty of Social Sciences
Utrecht University
P.O. Box 80140, 3508 TC Utrecht

Phone: +31 30 253 7983 / 4438 (secr.)
E-mail: Elly Korendijk

Supervisors: Prof. dr P.G.M. van der Heijden, dr M. Moerbeek, dr C. J.M. Maas
Project running from: 1 September 2005 – 1 September 2010

Summary

Cluster randomised trials randomise complete groups to treatment conditions. The estimates of the model parameters and their standard errors are only correct if the chosen statistical regression model includes all necessary fixed and random effects, and if the model assumptions are satisfied. Furthermore, optimal designs for cluster randomised trials depend on the values of certain model parameters, of which the true values must be specified in the design stage. This study researches two questions: What is the robustness of optimal designs and estimation methods? What should be done to correct for an incorrect model or an incorrect guess of the model parameters?

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